Epithalon — 3mg Capsules (30 Count) | Longevity Bioregulator

Description Epithalon (also spelled Epitalon) is a synthetic tetrapeptide bioregulator with the amino acid sequence Ala-Glu-Asp-Gly (AEDG), developed by Vladimir Khavinson and colleagues at the St. Petersburg Institute of Bioregulation and Gerontology. The peptide was originally derived from the protein structure of Epithalamin, a pineal gland extract studied extensively in Russian gerontology research since the 1960s. Epithalon is investigated as a Khavinson-class short peptide with proposed epigenetic regulatory activity, including studies reporting telomerase reactivation, telomere elongation in cell-culture models, and modulation of melatonin and serotonin biosynthesis in the pineal gland. Research interest extends to circadian rhythm regulation, age-associated gene expression patterns, antioxidant defense pathways, and longevity-related endpoints in rodent and human aging studies. Its small molecular weight (~390 Da) supports cellular uptake and is reported to enable direct DNA / chromatin interaction at gene promoter regions, consistent with the broader Khavinson bioregulator hypothesis. Benefits (Research Focus) • Studied as a Khavinson-class tetrapeptide bioregulator for epigenetic gene-expression modulation • Investigated for telomerase activity and telomere length in cell-culture models • Explored for pineal gland regulation and melatonin / serotonin biosynthesis • Examined for circadian rhythm research and sleep-wake cycle endpoints in aged models • Researched for geroprotective effects and age-associated gene expression patterns What Researchers Look At • Telomerase enzymatic activity and telomere length in human somatic cell cultures • Pineal gland melatonin synthesis enzymes (AANAT, ASMT) and circulating melatonin • AACG-motif binding affinity and promoter region transcriptional modulation • Antioxidant defense markers (SOD, catalase, glutathione peroxidase) in aged tissues • Comparative bioregulator pharmacology versus other Khavinson peptides (Pinealon, Cortagen, Vesugen) Quick Specs • Form: Gelatin capsule • Strength: 3 mg / capsule • Quantity: 30 capsules per bottle • Excipient: Microcrystalline cellulose (MCC) — pharmaceutical-grade filler • Purity: ≥99% • Storage: Store in a cool, dry, dark place Identity Basics • Compound: Epithalon • Synonyms: Epitalon; AEDG; Epithalamin tetrapeptide; H-Ala-Glu-Asp-Gly-OH • Class: Khavinson-class tetrapeptide bioregulator; pineal-derived short peptide • Sequence: Ala-Glu-Asp-Gly (AEDG) • Chemical Formula: C₁₄H₂₂N₄O₈ • Molecular Weight: 390.35 g/mol • CAS: 307297-39-8 ⚠️ Disclaimer This product is intended for laboratory research use only. Not for human or veterinary use. Not approved for diagnostic, therapeutic, or medical applications. Handle using appropriate laboratory safety procedures and personal protective equipment.